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Paula (Shirley) Berman Lab





Publications
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25 / Pinkas Z, Khersonsky O, Berman P, Kuzmich N, Rogachev I, Fleishman SJ, Aharoni A. Glycosylated cannabinoids in Cannabis sativa and enzyme design to modulate their synthesis. PNAS 2025, 122:e2515688122.
24 / Besser E, Gelfand A, Procaccia S, Berman P, Meiri D. Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway. eLife 2024, 12:RP90854.
​23 / Berman P, De-Haro LA, Cavaco AR, Panda S, Dong Y, Kuzmich N, Lichtenstein G, Peleg Y, Harat H, Jozwiak A, Cai J, Heinig U, Meir S, Rogachev I, Aharoni A. The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction. Mol Plant 2024, 17:1129–1150.
-- Research highlight in Nat Chem Biol - On the quest for mescaline
-- Dispatch in Curr Biol - Plant drugs: Transcending the mescaline biosynthesis
-- Weizmann Wonder Wander, Science news and culture - Cactus Dreams: Revealing the Secrets of Mescaline Making
​22 / Berman P*, De-Haro LA*, Jozwiak A*, Panda S, Pinkas Z, Dong Y, Cveticanin J, Barbole R, Livne R, Kopitman E, Scherf T, Shimoni E, Levin-Zaidman S, Meir S, Rogachev I, Sonawane PD, Aharoni A. Parallel evolution of cannabinoid biosynthesis. Nat Plants 2023, 9:817–831.
-- News and Views in Nat Plants - Turning a new leaf on cannabinoids
-- Research Highlight in Nature - Old and new cannabis compounds are found in an African herb
-- Research Highlight in Nature India - Previously unreported cannabis compounds found in perennial herb
-- Weizmann Wonder Wander, Science news and culture - Plant Research Reaches a New High​​
21 / Besser E, Gelfand A, Lewitus GM, Novac Kotzer H, Procaccia S, Berman P, Luria-Hayon I, Shreiber-Livne I, Ofran Y, Meiri D. Antitumoral effects of Cannabis in NOTCH1-mutated T-cell acute lymphoblastic leukemia. Cancer Commun 2023, 43:711–715.
20 / ​Procaccia S, Lewitus GM, Lipson-Feder C, Shapira A, Berman P, Meiri D. Cannabis for medical use: Versatile plant rather than a single drug. Front Pharmacol 2022, 13:894960.
19 / ​Lipson-Feder C, Cohen O, Shapira A, Katzir I, Peer R, Guberman O, Procaccia S, Berman P, Flaishman MA, Meiri D. Fertilization following pollination predominantly decreases phytocannabinoids accumulation and alters the accumulation of terpenoids in cannabis inflorescences. Front Plant Scie 2021, 12:753847.
​18 / Aviram J, Lewitus GM, Vysotski Y, Berman P, Shapira A, Procaccia S, Meiri D. Sex differences in medical cannabis related adverse effects. Pain 2021, 163:975–983.
17 / Aviram J, Lewitus GM, Pud D, Procaccia S, Berman P, Vysotski Y, Yellin B, Hazan O, Eisenberg E, Meiri D. Specific phytocannabinoid compositions are associated with analgesic response and adverse effects in chronic pain patients treated with medical cannabis. Pharmacol Res 2021, 169:105651.
16 / ​Aviram J, Lewitus GM, Vysotski Y, Yellin B, Berman P, Shapira A, Meiri D. Prolonged medical cannabis treatment is associated with quality of life improvement and reduction of analgesic medication consumption in chronic pain patients. Front Pharmacol 2021, 12:1199.
​15 / Milay L*, Berman P*, Guberman O, Shapira A, Meiri D. Metabolic profiling of Cannabis secondary metabolites for evaluation of optimal postharvest storage conditions. Front Plant Scie 2020, 11:1556.
14 / ​Bar-Sela G, Cohen I, Campisi-Pinto S, Lewitus GM, Oz-Ari L, Jehassi A, Peer A, Turgeman I, Vernicova O, Berman P, Wollner M, Moskovitz M, Meiri D. Cannabis consumption used by cancer patients during immunotherapy correlates with poor clinical outcome. Cancers 2020, 12:2447.
13 / ​Berman P*, Sulimani L*, Gelfand A, Amsalem K, Lewitus GM, Meiri D. Cannabinoidomics – An analytical approach to understand the effect of medical Cannabis treatment on the endocannabinoid metabolome. Talanta 2020, 219:121336.
12 / ​Aviram J, Vysotski Y, Berman P, Lewitus GM, Eisenberg E, Meiri D. Migraine frequency decrease following prolonged medical cannabis treatment: A cross-sectional study. Brain Sci 2020, 10:360. ​
11 / ​Uziel A, Gelfand A, Amsalem K, Berman P, Lewitus GM, Meiri D, Lewitus DY. Full-spectrum Cannabis extract microdepots support controlled release of multiple phytocannabinoids for extended therapeutic effect. ACS Appl Mater Interfaces 2020, 12:23707–23716.
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10 / ​Shapira A*, Berman P*, Futoran K, Guberman O, Meiri D. Tandem mass spectrometric quantification of 93 terpenoids in Cannabis using static headspace injections. Anal Chem 2019, 91:11425–11432.
9 / ​Baram L, Peled E, Berman P, Yellin B, Besser E, Benami M, Louria-Hayon I, Lewitus GM, Meiri D. The heterogeneity and complexity of Cannabis extracts as antitumor agents. Oncotarget 2019, 10:4091–4106.
8 / ​Berman P, Futoran K, Lewitus GM, Mukha D, Benami M, Shlomi T, Meiri D. A new ESI-LC/MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis. Sci Rep 2018, 8:14280.
​7 / Berman P, Meiri N, Linder C, Wiesman Z. 1H low field nuclear magnetic resonance relaxometry for probing biodiesel autoxidation. Fuel 2016, 177:315–325.
​6 / Meiri N*, Berman P*, Colnago LA, Moraes TB, Linder C, Wiesman Z. Liquid phase characterization of molecular interactions in polyunsaturated and N-fatty acid methyl esters by 1H low field nuclear magnetic resonance. Biotechnol Biofuels 2015, 8:96.
5 / ​Berman P, Meiri N, Colnago LA, Moraes TB, Linder C, Levi O, Parmet Y, Saunders M, Wiesman Z. Study of liquid phase molecular packing interactions and morphology of fatty acid methyl esters (biodiesel). Biotechnol Biofuels 2015, 8:12.
4 / ​Berman P, Leshem A, Etziony O, Levi O, Parmet Y, Saunders M, Wiesman Z. Novel 1H low field (LF)-NMR applications for the field of biodiesel. Biotechnol Biofuels 2013, 6:55.
3 / ​ Berman P, Levi O, Parmet Y, Saunders M, Wiesman Z. Laplace inversion of LR-NMR relaxometry data using sparse representation methods. Concept Magn Reson A 2013, 42:72-88.
​2 / Berman P, Nizri S, Wiesman Z. Castor oil biodiesel and its blends as alternative fuel. Biomass Bioenerg 2011, 35:2861-2866.
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1 / ​ Berman P, Nizri S, Parmet Y, Wiesman Z. Large-scale screening of intact castor seeds by viscosity using time-domain NMR and chemometrics. J Am Oil Chem Soc 2010, 87:1247-1254. ​​
*These authors contributed equally to the publication.
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